Usually when a company would jump all over a second printing when a series is hot enough to sell out.  Marvel is taking a different route though.  From their website:

We’re blown away by retailer and fan response to SIEGE,” said David Gabriel, Senior Vice-President of Sales and Circulation, Marvel Entertainment LLC. “I’ve seen what’s coming next and trust me, you’ll want to order even heavier on subsequent issues of Siege. This is the end of the Marvel Universe as you know it.”Marvel urges retailers to check their orders on SIEGE #1 DIRECTOR’S CUT, SIEGE #2 and all SIEGE tie-ins as they continue to sell out and garner acclaim!

Now, will Siege #1 Director’s Cut get a second printing if it sells out?